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CD34抗體

產(chǎn)品貨號：

BN42168R
中文名稱：

CD34抗體
英文名稱：

Rabbit anti-CD34 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42168R-50ul

50ul

￥2020.00

交叉反應：Rat,Mouse,Human(predicted:Dog) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN42168R-100ul

100ul

￥3240.00

交叉反應：Rat,Mouse,Human(predicted:Dog) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱	CD34
中文名稱	CD34抗體
別名	CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN.
研究領域	腫瘤心血管免疫學發(fā)育生物學神經(jīng)生物學干細胞細胞表面分子糖蛋白細胞類型標志物血管內(nèi)皮細胞內(nèi)皮細胞
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	7A1
交叉反應	Mouse, (predicted: Human, Rat, Dog, )
產(chǎn)品應用	ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	39kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human CD34:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
產(chǎn)品介紹	The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Post-translational modifications: Highly glycosylated. Phosphorylated on serine residues by PKC. Similarity: Belongs to the CD34 family. SWISS: P28906 Gene ID: 947 Database links: Entrez Gene: 947 Human Omim: 142230 Human SwissProt: P28906 Human Unigene: 374990 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 造血干細胞標志物內(nèi)皮標志物腫瘤生物標志物細胞表面的唾液粘蛋白。間充質(zhì)干細胞（mesenchymal stem cells,MSC）也是干細胞家族的重要成員，來源于發(fā)育早期的中胚層和外胚層。MSC最初在骨髓中發(fā)現(xiàn)，因其具有多向分化潛能、造血支持和促進干細胞植入、免疫調(diào)控和自我復制等特點。如間充質(zhì)干細胞在體內(nèi)或體外特定的誘導條件下，可分化為血管內(nèi)皮、脂肪、骨、軟骨、肌肉、肌腱、韌帶、神經(jīng)、肝、心肌、等多種組織細胞。