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細胞色素P450 17A1重組兔單克隆抗體

產(chǎn)品貨號：

BN42160R
中文名稱：

細胞色素P450 17A1重組兔單克隆抗體
英文名稱：

Rabbit anti-Cytochrome P450 17A1 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42160R-50ul

50ul

￥2020.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN42160R-100ul

100ul

￥3240.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	Cytochrome P450 17A1
中文名稱	細胞色素P450 17A1重組兔單克隆抗體
別名	CPT7; CYP17; CYP17A1; Cytochrome P450 17A1; CYPXVII; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia ; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; CP17A_HUMAN.
研究領域	腫瘤細胞生物免疫學
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	2F7
交叉反應	Human, Mouse, Rat,
產(chǎn)品應用	WB=1:500 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	57kDa
細胞定位	細胞膜
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	Recombinant human Cytochrome P450 17A1:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Cytochrome P450 17A1 (CYP17A1) belongs to the cytochrome P450 family; it plays a role in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 also catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. CYP17A1 is involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Subcellular Location: Membrane. Post-translational modifications: Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity. DISEASE: Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic). Similarity: Belongs to the cytochrome P450 family. SWISS: P05093 Gene ID: 1586 Database links: Entrez Gene: 493967 Cat Entrez Gene: 477807 Dog Entrez Gene: 101831170 Hamster Entrez Gene: 1586 Human Omim: 609300 Human SwissProt: Q9GMC8 Cat SwissProt: Q8HYN1 Chimpanzee SwissProt: P70687 Hamster SwissProt: Q95328 Horse SwissProt: P05093 Human Unigene: 438016 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.