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信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6重組兔單克隆抗體

產(chǎn)品貨號(hào)：

BN42114R
中文名稱：

信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6重組兔單克隆抗體
英文名稱：

Rabbit anti-STAT6 Monoclonal antibody
品牌：

Biorigin

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BN42114R-50ul

50ul

￥2020.00

交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
BN42114R-100ul

100ul

￥3240.00

交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

產(chǎn)品描述

英文名稱	STAT6
中文名稱	信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6重組兔單克隆抗體
別名	signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
研究領(lǐng)域	腫瘤發(fā)育生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡轉(zhuǎn)錄調(diào)節(jié)因子表觀遺傳學(xué)
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號(hào)	9A7
交叉反應(yīng)	Human, Mouse,
產(chǎn)品應(yīng)用	WB=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 Flow-Cyt=2ug/Test ICC=1:20-200 IF=1:20-200 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	94kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human STAT6 protein, around 700-800aa:
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif. Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated following stimulation by IL-4 and IL-3. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. SWISS: P42226 Gene ID: 6778 Database links: Entrez Gene: 6778 Human Entrez Gene: 20852 Mouse Entrez Gene: 362896 Rat Omim: 601512 Human SwissProt: P42226 Human SwissProt: P52633 Mouse Unigene: 524518 Human Unigene: 121721 Mouse Unigene: 6880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.