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促凋亡調(diào)節(jié)蛋白BNIP3抗體

產(chǎn)品貨號：

BN41899R
中文名稱：

促凋亡調(diào)節(jié)蛋白BNIP3抗體
英文名稱：

Rabbit anti-BNIP3 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN41899R-50ul

50ul

￥1486.00

交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應用：WB,Flow-Cyt,ELISA
BN41899R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應用：WB,Flow-Cyt,ELISA
BN41899R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	BNIP3
中文名稱	促凋亡調(diào)節(jié)蛋白BNIP3抗體
別名	BCL2 Adenovirus E1B 19kDa Interacting Protein 3; BCL2/adenovirus E1B 19 kDa protein interacting protein 3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP 3; BNIP3_HUMAN; NIP 3; NIP3.

研究領域	腫瘤心血管免疫學細胞凋亡
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	22kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human BNIP3:101-194/194
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. Subunit: Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Subcellular Location: Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Similarity: Belongs to the NIP3 family. SWISS: Q12983 Gene ID: 664 Database links: Entrez Gene: 664 Human Entrez Gene: 12176 Mouse Entrez Gene: 84480 Rat Omim: 603293 Human SwissProt: Q12983 Human SwissProt: O55003 Mouse Unigene: 144873 Human Unigene: 378890 Mouse Unigene: 2060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BNIP3蛋白在缺氧條件下可誘導細胞發(fā)生細胞凋亡。BNIP3促細胞凋亡線粒體途徑根據(jù)有無caspase的參與而具有不同的作用機制，也是研究的熱點。BNIP3還可誘導細胞自噬。BNIP3全稱為Bcl2/腺病毒E1B19kD相互作用蛋白3。(Bcl2/adenovirusE1B19kDainteractingprotein3，BNIP3)，是新近發(fā)現(xiàn)的BH3only亞家族成員之一，也是低氧敏感的凋亡基因。在化學性低氧誘導細胞凋亡的過程中，ATP是BNIP3導致細胞凋亡的關鍵性因素之一。單獨ATP下降不誘導細胞凋亡，但ATP下降到一定程度能促進BNIP3向線粒體轉(zhuǎn)位，從而誘導了BNIP3相關的凋亡。這可能是低氧誘導BNIP3表達導致細胞凋亡的重要機制之一。