貨號
產品規(guī)格
售價
備注
BN41803R-50ul
50ul
￥1486.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB
BN41803R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB
BN41803R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB
產品描述
| 英文名稱 | SA2 |
| 中文名稱 | 粘結蛋白SA2抗體 |
| 別 名 | Cohesin Subunit SA 2; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; SA 2; SA2; SCC3 homolog 2; STAG 2; STAG 2; stag2; STAG2_HUMAN; Stromal antigen 2; FLJ25871; bA517O1.1. |
| 研究領域 | 細胞生物 細胞周期蛋白 細胞分化 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產品應用 | WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 141kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SA2:1021-1120/1231 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Subunit: Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Subcellular Location: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. Post-translational modifications: Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity). Similarity: Belongs to the SCC3 family. Contains 1 SCD (stromalin conservative) domain. SWISS: Q8N3U4 Gene ID: 10735 Database links: UniProtKB/Swiss-Prot: Q8N3U4.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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