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膠質(zhì)細胞源性神經(jīng)營養(yǎng)因子抗體

產(chǎn)品貨號：

BN41628R
中文名稱：

膠質(zhì)細胞源性神經(jīng)營養(yǎng)因子抗體
英文名稱：

Rabbit anti-GDNF Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN41628R-50ul

50ul

￥1486.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41628R-100ul

100ul

￥2360.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41628R-200ul

200ul

￥3490.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱	GDNF
中文名稱	膠質(zhì)細胞源性神經(jīng)營養(yǎng)因子抗體
別名	glial cell line derived neurotrophic factor; Astrocyte derived trophic factor 1; Astrocyte derived trophic factor; ATF 1; ATF 2; ATF1; ATF2; Glial cell derived neurotrophic factor; Glial derived neurotrophic factor; HFB1 GDNF; GDNF_HUMAN; Atf; gdnf; Glial Cell Line Derived Neurotrophic Factor; Glial cell line-derived neurotrophic factor; Glial derived neurotrophic factor; hGDNF; HSCR3.

研究領(lǐng)域	神經(jīng)生物學(xué) 細胞凋亡生長因子和激素
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	15kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GDNF:121-211/211
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Neurobiology. Neurotrophins. Neuroscience. This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Subunit: Homodimer; disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3) [MIM:613711]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Similarity: Belongs to the TGF-beta family. GDNF subfamily. SWISS: P39905 Gene ID: 2668 Database links: Entrez Gene: 2668 Human Entrez Gene: 14573 Mouse Entrez Gene: 25453 Rat Omim: 600837 Human SwissProt: P39905 Human SwissProt: P48540 Mouse SwissProt: Q07731 Rat Unigene: 248114 Human Unigene: 4679 Mouse Unigene: 53970 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白