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磷酸化水通道蛋白2抗體

產(chǎn)品貨號：

BN41014R
中文名稱：

磷酸化水通道蛋白2抗體
英文名稱：

Rabbit anti-phospho-AQP2 (Ser264+261) Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN41014R-100ul

100ul

￥2470.00

交叉反應：Dog(predicted:Human,Mouse,Rat,Chicken,Pig,Cow,Sheep) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱	phospho-AQP2 (Ser264+261)
中文名稱	磷酸化水通道蛋白2抗體
別名	Aquaporin 2 (phospho S261); p-Aquaporin 2 (phospho S261) ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD.
產(chǎn)品類型	磷酸化抗體
研究領域	腫瘤細胞生物信號轉(zhuǎn)導通道蛋白細胞粘附分子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Dog, (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	30kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human AQP2 around the phosphorylation site of Ser264/261:LH(p-S)PQ(p-S)LP <Cytoplasmic>
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus. Belongs to the MIP/aquaporin (TC 1.A.8) family. Function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Tissue Specificity: Expressed in renal collecting tubules. Post-translational modifications: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. DISEASE: Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. SWISS: P41181 Gene ID: 359 Database links: Entrez Gene: 359 Human Entrez Gene: 11827 Mouse Entrez Gene: 25386 Rat Omim: 107777 Human SwissProt: P41181 Human SwissProt: P56402 Mouse SwissProt: P34080 Rat Unigene: 130730 Human Unigene: 20206 Mouse Unigene: 90076 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.